| Unlockable | How to Unlock |
| Bluff (10 points) | Bluff on a Wild Draw Four twice in the same game. |
| Multiplayer (10 points) | Complete a 4-player game of UNO in any mode on Xbox Live. |
| UNO! (10 points) | Successfully get UNO! and win the game. |
| High Noon (15 points) | Play 40 Draw Two cards. |
| Quick Change Artist (15 points) | Change the color of the discard pile at least five times in a single round. |
| Skip to My Lou (15 points) | Play 40 Skip cards. |
| Twister (15 points) | Play 40 Reverse cards. |
| Wild Thing (15 points) | Successfully play 40 Wild or Wild Draw Four cards. |
| Wild Abandon (20 points) | Go out with a Wild or Wild Draw Four card. |
| Ace! (20 points) | Go out without drawing a card. |
| Devotee (25 points) | Win 40 games of UNO. |
| UNO Shark (30 points) | Win ten 4-player games of UNO in any mode on Xbox Live. |
